In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

被引：28

作者：

Hoellman, DB

Kelly, LM

Credito, K

Anthony, L

Ednie, LM

Jacobs, MR

Appelbaum, PC

机构：

[1] Case Western Reserve Univ, Dept Pathol Clin Microbiol, Cleveland, OH 44106 USA

[2] Milton S Hershey Med Ctr, Dept Pathol Clin Microbiol, Hershey, PA 17033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 01期

关键词：

D O I：

10.1128/AAC.46.1.220-224.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active beta -lactams (MICs at which 50% of the strains are inhibited [MIC(50)s], 0.125 to 0.25 mug/ml; MIC(90)s, 1.0 to 2.0 mug/ml). Time-kill studies revealed that ertapenem, at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other beta -lactams were similar to those of ertapenem.

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页码：220 / 224

页数：5

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