Common markers of proliferation

被引：480

作者：

Whitfield, ML

George, LK

Grant, GD

Perou, CM

机构：

[1] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA

[2] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Norris Cotton Canc Ctr, Hanover, NH 03755 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pathol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1038/nrc1802

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

When normal tissue and tumour samples are compared by microarray analysis, the biggest differences most often occur in the expression levels of genes that control cell proliferation. However, this difference is detected whenever mRNA samples that are taken from two cell populations with different proliferation rates are compared. Although the exact genes that comprise this 'proliferation signature' often differ, they are almost always genes that are involved in the fundamental process of cell proliferation. Can the proliferation signature be used to improve our understanding of the cell cycle and cancer pathogenesis, as well as being used as a biomarker for cancer diagnosis and prognosis?

引用

页码：99 / 106

页数：8

共 68 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2]

Allegra Carmen J., 1997, P432

[3] FUNCTIONALLY HOMOLOGOUS CELL-CYCLE CONTROL GENES IN BUDDING AND FISSION YEAST [J].

BEACH, D ;

DURKACZ, B ;

NURSE, P .

NATURE, 1982, 300 (5894) :706-709

[4] Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses [J].

Bhattacharjee, A ;

Richards, WG ;

Staunton, J ;

Li, C ;

Monti, S ;

Vasa, P ;

Ladd, C ;

Beheshti, J ;

Bueno, R ;

Gillette, M ;

Loda, M ;

Weber, G ;

Mark, EJ ;

Lander, ES ;

Wong, W ;

Johnson, BE ;

Golub, TR ;

Sugarbaker, DJ ;

Meyerson, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13790-13795

[5] STUDIES ON SYNCHRONOUS DIVISION OF TISSUE CULTURE CELLS INITIATED BY EXCESS THYMIDINE [J].

BOOTSMA, D ;

VOS, O ;

BUDKE, L .

EXPERIMENTAL CELL RESEARCH, 1964, 33 (1-2) :301-&

[6] GO::TermFinder - open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes [J].

Boyle, EI ;

Weng, SA ;

Gollub, J ;

Jin, H ;

Botstein, D ;

Cherry, JM ;

Sherlock, G .

BIOINFORMATICS, 2004, 20 (18) :3710-3715

[7] Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival [J].

Chang, HY ;

Nuyten, DSA ;

Sneddon, JB ;

Hastie, T ;

Tibshirani, R ;

Sorlie, T ;

Dai, HY ;

He, YDD ;

van't Veer, LJ ;

Bartelink, H ;

van de Rijn, M ;

Brown, PO ;

van de Vijver, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3738-3743

[8] Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds [J].

Chang, HY ;

Sneddon, JB ;

Alizadeh, AA ;

Sood, R ;

West, RB ;

Montgomery, K ;

Chi, JT ;

van de Rijn, M ;

Botstein, D ;

Brown, PO .

PLOS BIOLOGY, 2004, 2 (02) :206-214

[9] Aberrant expression of minichromosome maintenance protein-2 and Ki67 in laryngeal squamous epithelial lesions [J].

Chatrath, P ;

Scott, IS ;

Morris, LS ;

Davies, RJ ;

Rushbrook, SM ;

Bird, K ;

Vowler, SL ;

Grant, JW ;

Saeed, IT ;

Howard, D ;

Laskey, RA ;

Coleman, N .

BRITISH JOURNAL OF CANCER, 2003, 89 (06) :1048-1054

[10] Gene expression patterns in human liver cancers [J].

Chen, X ;

Cheung, ST ;

So, S ;

Fan, ST ;

Barry, C ;

Higgins, J ;

Lai, KM ;

Ji, JF ;

Dudoit, S ;

Ng, IOL ;

van de Rijn, M ;

Botstein, D ;

Brown, PO .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (06) :1929-1939

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