Increased granulocyte aggregation in vitro in diabetes mellitus

被引:15
作者
Elhadd, TA
Bancroft, A
McLaren, M
Newton, RW
Belch, JJF
机构
[1] University Department of Medicine, Ninewells Hosp. and Medical School, Dundee
[2] University Department of Medicine, Ninewells Hosp. and Medical School
来源
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS | 1997年 / 90卷 / 07期
关键词
D O I
10.1093/qjmed/90.7.461
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique, WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean +/- SD 31.10 +/- 10.26% vs. 25.7 +/- 9.38%; p < 0.04. Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.
引用
收藏
页码:461 / 464
页数:4
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