Classifying collective cancer cell invasion

被引：702

作者：

Friedl, Peter ^{[1
,2
]}

Locker, Joseph ^{[3
]}

Sahai, Erik ^{[4
]}

Segall, Jeffrey E. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, NCMLS, Dept Cell Biol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77230 USA

[3] Albert Einstein Coll Med, Bronx, NY 10461 USA

[4] Canc Res UK London Res Inst, Tumour Cell Biol Lab, London WC2A 3LY, England

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 08期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITIONS; BETA SIGNALING SWITCHES; MULTIPHOTON MICROSCOPY; TUMOR-CELLS; E-CADHERIN; MIGRATION; PLASTICITY; MOVEMENT; MORPHOGENESIS; CARCINOMA;

D O I：

10.1038/ncb2548

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.

引用

页码：777 / 783

页数：7

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