DNA-Mediated Electrochemistry

被引：136

作者：

Gorodetsky, Alon A. ^{[1
]}

Buzzeo, Marisa C. ^{[1
]}

Barton, Jacqueline K. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 12期

关键词：

D O I：

10.1021/bc8003149

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here, we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry.

引用

页码：2285 / 2296

页数：12

共 79 条

[1] The role of surface charging during the coadsorption of mercaptohexanol to DNA layers on gold: Direct observation of desorption and layer reorientation
Arinaga, K.
Rant, U.
Tornow, M.
Fujita, S.
Abstreiter, G.
Yokoyama, N.
[J]. LANGMUIR, 2006, 22 (13) : 5560 - 5562
[2] Influence of intervening mismatches on long-range guanine oxidation in DNA duplexes
Bhattacharya, PK
Barton, JK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (36) : 8649 - 8656
[3] Electrochemical detection of lesions in DNA
Boal, AK
Barton, JK
[J]. BIOCONJUGATE CHEMISTRY, 2005, 16 (02) : 312 - 321
[4] DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters
Boal, AK
Yavin, E
Lukianova, OA
O'Shea, VL
David, SS
Barton, JK
[J]. BIOCHEMISTRY, 2005, 44 (23) : 8397 - 8407
[5] Mutation detection by electrocatalysis at DNA-modified electrodes
Boon, EM
Ceres, DM
Drummond, TG
Hill, MG
Barton, JK
[J]. NATURE BIOTECHNOLOGY, 2000, 18 (10) : 1096 - 1100
[6] DNA Electrochemistry as a probe of base pair stacking in A-, B-, and Z-form DNA
Boon, EM
Barton, JK
[J]. BIOCONJUGATE CHEMISTRY, 2003, 14 (06) : 1140 - 1147
[7] DNA-mediated charge transport for DNA repair
Boon, EM
Livingston, AL
Chmiel, NH
David, SS
Barton, JK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) : 12543 - 12547
[8] Intercalative stacking: A critical feature of DNA charge-transport electrochemistry
Boon, EM
Jackson, NM
Wightman, MD
Kelley, SO
Hill, MG
Barton, JK
[J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (42) : 11805 - 11812
[9] Reduction of ferricyanide by methylene blue at a DNA-modified rotating-disk electrode
Boon, EM
Barton, JK
Bhagat, V
Nersissian, M
Wang, W
Hill, MG
[J]. LANGMUIR, 2003, 19 (22) : 9255 - 9259
[10] Charge transport in DNA
Boon, EM
Barton, JK
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (03) : 320 - 329

← 1 2 3 4 5 6 7 8 →