An enantioselective synthesis of sulphonamide hydroxamic acids as matrix metalloproteinase inhibitors

被引:59
作者
Watson, RJ [1 ]
Batty, D [1 ]
Baxter, AD [1 ]
Hannah, DR [1 ]
Owen, DA [1 ]
Montana, JG [1 ]
机构
[1] Celltech R&D Ltd, Cambridge CB1 6GS, England
关键词
MMP; hydroxamic acid; sulphonamide; oxazolidinone;
D O I
10.1016/S0040-4039(01)02151-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A high yielding and enantioselective synthesis of alpha-substituted hydroxamic acids as inhibitors of matrix metalloproteinases is described. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:683 / 685
页数:3
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