Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer

被引：14

作者：

Thakur, Bhupesh K. ^{[1
]}

Malaise, Yann ^{[1
]}

Martin, Alberto ^{[1
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M5B 1W8, Canada

来源：

MOLECULAR CELL | 2019年 / 74卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2019.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

收藏

页码：227 / 229

页数：3

相关论文

共 10 条

[1]

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].

Arthur, Janelle C. ;

Perez-Chanona, Ernesto ;

Muehlbauer, Marcus ;

Tomkovich, Sarah ;

Uronis, Joshua M. ;

Fan, Ting-Jia ;

Campbell, Barry J. ;

Abujamel, Turki ;

Dogan, Belgin ;

Rogers, Arlin B. ;

Rhodes, Jonathan M. ;

Stintzi, Alain ;

Simpson, Kenneth W. ;

Hansen, Jonathan J. ;

Keku, Temitope O. ;

Fodor, Anthony A. ;

Jobin, Christian .

SCIENCE, 2012, 338 (6103) :120-123

[2]

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells [J].

Bossuet-Greif, Nadege ;

Vignard, Julien ;

Taieb, Frederic ;

Mirey, Gladys ;

Dubois, Damien ;

Petit, Claude ;

Oswald, Eric ;

Nougayrede, Jean-Philippe .

MBIO, 2018, 9 (02)

[3]

Escherichia coliClbS is a colibactin resistance protein [J].

Bossuet-Greif, Nadege ;

Dubois, Damien ;

Petit, Claude ;

Tronnet, Sophie ;

Martin, Patricia ;

Bonnet, Richard ;

Oswald, Eric ;

Nougayrede, Jean-Philippe .

MOLECULAR MICROBIOLOGY, 2016, 99 (05) :897-908

[4]

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria [J].

Dejea, Christine M. ;

Fathi, Payam ;

Craig, John M. ;

Boleij, Annemarie ;

Taddese, Rahwa ;

Geis, Abby L. ;

Wu, Xinqun ;

Shields, Christina E. DeStefano ;

Hechenbleikner, Elizabeth M. ;

Huso, David L. ;

Anders, Robert A. ;

Giardiello, Francis M. ;

Wick, Elizabeth C. ;

Wang, Hao ;

Wu, Shaoguang ;

Pardoll, Drew M. ;

Housseau, Franck ;

Sears, Cynthia L. .

SCIENCE, 2018, 359 (6375) :592-+

[5]

Colibactin: More Than a New Bacterial Toxin [J].

Fais, Tiphanie ;

Delmas, Julien ;

Barnich, Nicolas ;

Bonnet, Richard ;

Dalmasso, Guillaume .

TOXINS, 2018, 10 (04)

[6]

A Mechanistic Model for Colibactin-Induced Genotoxicity [J].

Healy, Alan R. ;

Nikolayevskiy, Herman ;

Patel, Jaymin R. ;

Crawford, Jason M. ;

Herzon, Seth B. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (48) :15563-15570

[7]

Escherichia coli induces DNA double-strand breaks in eukaryotic cells [J].

Nougayrede, Jean-Philippe ;

Homburg, Stefan ;

Taieb, Frederic ;

Boury, Michele ;

Brzuszkiewicz, Elzbieta ;

Gottschalk, Gerhard ;

Buchrieser, Carmen ;

Hacker, Joerg ;

Dobrindt, Ulrich ;

Oswald, Eric .

SCIENCE, 2006, 313 (5788) :848-851

[8]

Vizcaino MI, 2015, NAT CHEM, V7, P411, DOI [10.1038/NCHEM.2221, 10.1038/nchem.2221]

[9]

The human gut bacterial genotoxin colibactin alkylates DNA [J].

Wilson, Matthew R. ;

Jiang, Yindi ;

Villalta, Peter W. ;

Stornetta, Alessia ;

Boudreau, Paul D. ;

Carra, Andrea ;

Brennan, Caitlin A. ;

Chun, Eunyoung ;

Ngo, Lizzie ;

Samson, Leona D. ;

Engelward, Bevin P. ;

Garrett, Wendy S. ;

Balbo, Silvia ;

Balskus, Emily P. .

SCIENCE, 2019, 363 (6428) :709-+

[10]

Characterization of Natural-Colibactin Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening [J].

Xue, Mengzhao ;

Shine, Emilee ;

Wang, Weiwei ;

Crawford, Jason M. ;

Herzon, Seth B. .

BIOCHEMISTRY, 2018, 57 (45) :6391-6394