Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

被引：5

作者：

Fauq, AH

Zaidi, JH

Wilcox, RA

Varvel, G

Nahorski, SR

Kozikowski, AP

Erneux, C

机构：

[1] UNIV LEICESTER,DEPT CELL PHYSIOL & PHARMACOL,LEICESTER LE1 9HN,LEICS,ENGLAND

[2] GEORGETOWN UNIV,MED CTR,INST COGNIT & COMPUTAT SCI,WASHINGTON,DC 20007

[3] FREE UNIV BRUSSELS,FAC MED,INST RECH INTERDISCIPLINAIRE BIOL HUMAINE & NUCL,BRUSSELS,BELGIUM

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期

关键词：

D O I：

10.1016/0040-4039(96)00169-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

引用

页码：1917 / 1920

页数：4

共 15 条

[1]

[Anonymous], 1993, The inositol phosphates: chemical synthesis and biological significance

[2]

BERRIDGE M, 1993, NATURE, P315

[3] INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL - 2 INTERACTING 2ND MESSENGERS [J].