H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

被引：483

作者：

Zhang, Qianyi ^{[1
,2
]}

Shi, Jianzhong ^{[1
]}

Deng, Guohua ^{[1
]}

Guo, Jing ^{[1
]}

Zeng, Xianying ^{[1
]}

He, Xijun ^{[1
]}

Kong, Huihui ^{[1
]}

Gu, Chunyang ^{[1
,2
]}

Li, Xuyong ^{[1
]}

Liu, Jinxiong ^{[1
]}

Wang, Guojun ^{[1
,2
]}

Chen, Yan ^{[1
]}

Liu, Liling ^{[1
]}

Liang, Libin ^{[1
]}

Li, Yuanyuan ^{[1
]}

Fan, Jun ^{[1
]}

Wang, Jinliang ^{[1
]}

Li, Wenhui ^{[1
]}

Guan, Lizheng ^{[1
]}

Li, Qimeng ^{[1
,2
]}

Yang, Huanliang ^{[1
]}

Chen, Pucheng ^{[1
]}

Jiang, Li ^{[1
]}

Guan, Yuntao ^{[1
]}

Xin, Xiaoguang ^{[1
]}

Jiang, Yongping ^{[1
]}

Tian, Guobin ^{[1
]}

Wang, Xiurong ^{[1
]}

Qiao, Chuanling ^{[1
]}

Li, Chengjun ^{[1
]}

Bu, Zhigao ^{[1
]}

Chen, Hualan ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Peoples R China

[2] Gansu Agr Univ, Coll Vet Med, Lanzhou 730030, Peoples R China

来源：

SCIENCE | 2013年 / 341卷 / 6144期

关键词：

SINGLE AMINO-ACID; A VIRUS; RECEPTOR SPECIFICITY; MOLECULAR-BASIS; MOUSE MODEL; GUINEA-PIG; HOST-RANGE; HEMAGGLUTININ; POULTRY; HUMANS;

D O I：

10.1126/science.1240532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.

引用

页码：410 / 414

页数：5

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