Alzheimer's Disease, Ceramide, Visfatin and NAD

被引：19

作者：

Adams, James D., Jr. ^{[1
]}

机构：

[1] Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2008年 / 7卷 / 06期

关键词：

Alzheimer's disease; ceramide; visfatin; NAD; oxidative stress;

D O I：

10.2174/187152708787122969

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

This review discusses new mechanisms for the induction of Alzheimer's disease, involving lipid toxicity and adipokines. Ceramide induces oxidative stress and the formation of amyloid Visfatin induces oxidative stress, damages the blood brain barrier and increases the attraction of monocytes, neutrophils and other white blood cells. A new mechanism for visfatin/NAD (nicotinamide adenine dinucleotide)-induced oxidative stress is presented involving redox cycling catalyzed by xanthine dehydrogenase and NADH oxidase. These mechanisms are discussed in terms of the treatment of Alzheimer's disease.

引用

页码：492 / 498

页数：7

共 66 条

[1]

Adams JD, 2007, LETT DRUG DES DISCOV, V4, P44

[2]

Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke [J].

Altura, BM ;

Gebrewold, A ;

Zheng, T ;

Altura, BT .

BRAIN RESEARCH BULLETIN, 2002, 58 (03) :271-278

[3]

Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells [J].

Arboleda, Gonzalo ;

Huang, Tze-Jen ;

Waters, Catherine ;

Verkhratsky, Alex ;

Fernyhough, Paul ;

Gibson, Rosemary M. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 25 (10) :3030-3038

[4]

Arvanitakis, Z. ;

Schneider, J. A. ;

Wilson, R. S. ;

Li, Y. ;

Arnold, S. E. ;

Wang, Z. ;

Bennett, D. A. .

NEUROLOGY, 2006, 67 (11) :1960-1965

[5]

A SENSITIVE FLUOROMETRIC ASSAY FOR MEASURING XANTHINE DEHYDROGENASE AND OXIDASE IN TISSUES [J].

BECKMAN, JS ;

PARKS, DA ;

PEARSON, JD ;

MARSHALL, PA ;

FREEMAN, BA .

FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (06) :607-615

[6]

NAD+ metabolism in health and disease [J].

Belenky, Peter ;

Bogan, Katrina L. ;

Brenner, Charles .

TRENDS IN BIOCHEMICAL SCIENCES, 2007, 32 (01) :12-19

[7]

The new life of a centenarian:: signalling functions of NAD(P) [J].

Berger, F ;

Ramírez-Hernández, MH ;

Ziegler, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (03) :111-118

[8]

Abdominal obesity: Role in the pathophysiology of metabolic disease and cardiovascular risk [J].

Bergman, Richard N. ;

Kim, Stella P. ;

Hsu, Isabel R. ;

Catalano, Karyn J. ;

Chiu, Jenny D. ;

Kabir, Morvarid ;

Richey, Joyce M. ;

Ader, Marilyn .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (2A) :S3-S8

[9]

The role of insulin in human brain glucose metabolism -: An 18fluoro-deoxyglucose positron emission tomography study [J].

Bingham, EM ;

Hopkins, D ;

Smith, D ;

Pernet, A ;

Hallett, W ;

Reed, L ;

Marsden, PK ;

Amiel, SA .

DIABETES, 2002, 51 (12) :3384-3390

[10]

Birkmayer JGD, 1996, ANN CLIN LAB SCI, V26, P1

← 1 2 3 4 5 6 7 →