Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?

被引：45

作者：

Bates, Jennifer ^{[1
]}

Diehl, Lauri ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

JOURNAL OF PATHOLOGY | 2014年 / 232卷 / 02期

关键词：

inflammatory bowel disease; dendritic cell; mucosal immunity; colitis; Crohn's disease; inflammation; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; REGULATORY T-CELLS; CROHNS-DISEASE; ULCERATIVE-COLITIS; FECAL STREAM; TRANSCRIPTION FACTOR; PROBIOTIC BACTERIA; MASTER REGULATORS; TL1A TNFSF15;

D O I：

10.1002/path.4277

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape. (c) 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

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收藏

页码：112 / 120

页数：9

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