Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death

被引：68

作者：

Heinhuis, Bas ^{[1
,2
]}

Netea, Mihai G. ^{[1
,3
]}

van den Berg, Wim B. ^{[2
]}

Dinarello, Charles A. ^{[1
,4
]}

Joosten, Leo A. B. ^{[1
,3
]}

机构：

[1] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands

[4] Univ Colorado Denver, Div Infect Dis, Aurora, CO 80045 USA

来源：

CYTOKINE | 2012年 / 60卷 / 02期

关键词：

Cytokines; IL-32; Inflammation; Cell death; Autoimmune diseases; RNA INTERFERENCE; IL-32; CYTOKINE; DIFFERENTIATION; INFLAMMATION; ALPHA; RGD; IL-32-GAMMA; EXPRESSION; IL-1-BETA;

D O I：

10.1016/j.cyto.2012.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1 alpha, IL-33, and IL-37, with both intracellular and extracellular functions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：321 / 327

页数：7

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