Combination therapy with immune-modulators and moxifloxacin on fulminant macrolide-resistant Mycoplasma pneumoniae infection: A case report

被引：40

作者：

Shen, Yuelin ^{[1
]}

Zhang, Jin ^{[1
]}

Hu, Yinghui ^{[1
]}

Shen, Kunling ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Resp Dept, Beijing 100045, Peoples R China

来源：

PEDIATRIC PULMONOLOGY | 2013年 / 48卷 / 05期

关键词：

Mycoplasma pneumoniae; macrolide resistance; methylprednisolone pulse therapy; moxifloxacin; children; CHILDHOOD;

D O I：

10.1002/ppul.22650

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

This report entails a case of refractory pneumonia with a wild variety of extra-pulmonary manifestations due to macrolide-resistant Mycoplasma pneumoniae infection in a 7-year-old boy. The diagnosis was based on isolating M. pneumoniae through cultivation from the patient's bronchial aspirations at admission and the following susceptibility testing. Initial treatments consisting of a combination of azithromycin and standard-dosed methylprednisone (2mg/kg) were completely nonresponsive and the patient's condition deteriorated rapidly. However, methylprednisone pulse therapy (20mg/kg for 3 days, tapering within 1 month) and intravenous immunoglobulin (1g/kg/day, two doses), in addition to moxifloxacin (10mg/kg for 7 days) were remarkably effective and led to a favorable outcome without any observed side effects during inpatient hospitalization and outpatient follow-up. Pediatr Pulmonol. 2013; 48:519522. (c) 2012 Wiley Periodicals, Inc.

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收藏

页码：519 / 522

页数：4

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