Triterpenoid Saponins with Anti-Inflammatory Activity from Codonopsis lanceolata

被引：71

作者：

Xu, Li-Ping

Wang, Hao ^{[2
]}

Yuan, Zhong ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Anal Tradit Chinese Med, Shenyang 110016, Peoples R China

[2] Jilin Univ, Clin Hosp 1, Changchun 130023, Peoples R China

来源：

PLANTA MEDICA | 2008年 / 74卷 / 11期

关键词：

Codonopsis lanceolata Benth. et Hook; Campanulaceae; triterpenoid saponins; anti-inflammatory activity;

D O I：

10.1055/s-2008-1081318

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Six triterpenoid saponins, including a new compound named codonolaside 111, were isolated from the roots of Codonopsis lanceolata. The spectral and chemical data revealed the structure of coclonolaside III to be 3-O-[beta-D-xylopyranosyl-(1 -> 3)-beta-D-glucuronopyranosyl]-3 beta,16 alpha-dihydroxyolean-12-ene-28-oic acid 28-O-[beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnpyranosyl-(1 -> 2)][beta-D-glucopyranosyl -(1 -> 4)]-alpha-L-arabinopyranosyl ester. The xylene-induced mouse ear edema inhibitory effect assay disclosed coclonolaside and codonolasides I - III as the major anti-inflammatory constituents in this crude drug.

引用

页码：1412 / 1415

页数：4

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