Danggui-Shaoyao-San, a traditional Chinese prescription, suppresses PGF2α production in endometrial epithelial cells by inhibiting COX-2 expression and activity

被引：33

作者：

Hua, Y. Q. ^{[1
,2
]}

Su, S. L. ^{[1
]}

Duan, J. A. ^{[1
,2
]}

Wang, Q. J. ^{[4
]}

Lu, Y. ^{[1
]}

Chen, L. ^{[3
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

[2] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 210038, Peoples R China

[3] Nanjing Univ Chinese Med, Natl Standard Lab Pharmacol Chinese Mat Med, Nanjing 210029, Peoples R China

[4] China Pharmaceut Univ, Dept Physiol, Nanjing 210009, Peoples R China

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 12期

关键词：

Danggui-Shaoyao-San; Dysmenorrhoca; Prostaglandin F-2 alpha; Cyclooxygenase-2; Oxytocin;

D O I：

10.1016/j.phymed.2008.06.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Danggul-Shaoyao-San, a famous traditional Chinese prescription, has been widely used in China for treating various gynecological inflammatory diseases including dysmenorrhea, but it is still poorly understood how it works on those inflammatory disorders. Prostaglandin F-2 alpha (PGF(2 alpha)), one important mediators of inflammation, plays crucial roles in the pathological mechanism responsible for dysmenorrhea. Here, we demonstrate that Danggul-Shaoyao-San significantly suppresses oxytocin-evoked PGF(2 alpha) production of rat endometrial epithelial cells in a concentration-dependent manner. Furthermore, Danggui-Shaoyao-San-mediated down-regulation of cyclooxygenases-2 message RNA transcription, protein expression and enzyme activity in endometrial epithelial cells may be involved in the inhibitory effect on PGF(2 alpha) production. Our study provides a possible mechanism for the bioactivity of Danggui-Shaoyao-San for treating dysmenorrhea and other gynecological disorders. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：1046 / 1052

页数：7

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