The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis

被引：54

作者：

Ibrahim, AS

Spellberg, BJ

Avanesian, V

Fu, Y

Edwards, JE

机构：

[1] Univ Calif Los Angeles, Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Med,Div Infect Dis, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 05期

关键词：

D O I：

10.1128/IAI.74.5.3039-3041.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously shown that vaccination with a vaccine based on the recombinant N-terminal domain of Als1p (rAls1p-N) protected BALB/c mice against disseminated infection caused by a single strain of Candida albicans (A. S. Ibrahim, B. J. Spellberg, V. Avenissian, Y. Fu, S. G. Filler, and J. E. Edwards, Jr., Infect. Immun. 73:999-1005, 2005, and B. J. Spellberg, A. S. Ibrahim, V. Avenissian, S. G. Filler, C. Myers, Y. Fu, and J. E. Edwards, Jr., Infect. Immun. 73:6191-6193, 2005). Here we show that the rAls1p-N vaccine also improves survival of outbred mice front disseminated candidiasis and that it is active against multiple virulent strains of C. albicans and non-C. albicans spp.

引用

页码：3039 / 3041

页数：3

共 15 条

[1] An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells [J].

Cormack, BP ;

Ghori, N ;

Falkow, S .

SCIENCE, 1999, 285 (5427) :578-582

[2] Modular domain structure in the Candida glabrata adhesin Epa1p, a β1,6 glucan-cross-linked cell wall protein [J].

Frieman, MB ;

McCaffery, JM ;

Cormack, BP .

MOLECULAR MICROBIOLOGY, 2002, 46 (02) :479-492

[3] Attributable mortality of nosocomial candidemia, revisited [J].

Gudlaugsson, O ;

Gillespie, S ;

Lee, K ;

Berg, JV ;

Hu, JF ;

Messer, S ;

Herwaldt, L ;

Pfaller, M ;

Diekema, D .

CLINICAL INFECTIOUS DISEASES, 2003, 37 (09) :1172-1177

[4]

Hoyer LL, 2001, GENETICS, V157, P1555

[5] EVIDENCE IMPLICATING PHOSPHOLIPASE AS A VIRULENCE FACTOR OF CANDIDA-ALBICANS [J].

IBRAHIM, AS ;

MIRBOD, F ;

FILLER, SG ;

BANNO, Y ;

COLE, GT ;

KITAJIMA, Y ;

EDWARDS, JE ;

NOZAWA, Y ;

GHANNOUM, MA .

INFECTION AND IMMUNITY, 1995, 63 (05) :1993-1998

[6] Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity [J].

Ibrahim, AS ;

Spellberg, BJ ;

Avenissian, V ;

Fu, Y ;

Filler, SG ;

Edwards, JE .

INFECTION AND IMMUNITY, 2005, 73 (02) :999-1005

[7] FUNGEMIA IN PATIENTS WITH LEUKEMIA [J].

MARTINO, P ;

GIRMENIA, C ;

MICOZZI, A ;

RACCAH, R ;

GENTILE, G ;

VENDITTI, M ;

MANDELLI, F .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1993, 306 (04) :225-232

[8]

Nucci Marcio, 1995, Revista do Instituto de Medicina Tropical de Sao Paulo, V37, P397, DOI 10.1590/S0036-46651995000500004

[9] Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated) [J].

Opal, SM ;

Garber, GE ;

LaRosa, SP ;

Maki, DG ;

Freebairn, RC ;

Kinasewitz, GT ;

Dhainaut, JF ;

Yan, SB ;

Williams, MD ;

Graham, DE ;

Nelson, DR ;

Levy, H ;

Bernard, GR .

CLINICAL INFECTIOUS DISEASES, 2003, 37 (01) :50-58

[10] Functional and structural diversity in the Als protein family of Candida albicans [J].

Sheppard, DC ;

Yeaman, MR ;

Welch, WH ;

Phan, QT ;

Fu, Y ;

Ibrahim, AS ;

Filler, SG ;

Zhang, M ;

Waring, AJ ;

Edwards, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) :30480-30489

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