Preparation of N-H aziridines in high enantiomeric excess by in situ aziridine-azirine-aziridine interconversion

被引：16

作者：

Atkinson, RS

Coogan, MP

Lochrie, IST

机构：

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 06期

关键词：

D O I：

10.1039/cc9960000789

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aziridine 6 is produced highly diastereoselectively by treatment of enantiopure 3-acetoxyaminoquinazolinone 4 (Q*NHOAc) with beta-trimethylsilylstyrene: desilylative elimination of Q* and in situ addition of cyanide to the intermediate azirine gives the NH-aziridine 8 of 83% ee.

引用

页码：789 / 790

页数：2

共 9 条

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