Mercadeo Virus: A Novel Mosquito-Specific Flavivirus from Panama

被引:18
作者
Carrera, Jean-Paul [1 ,3 ]
Guzman, Hilda [4 ,5 ]
Beltran, Davis [1 ]
Diaz, Yamilka [1 ]
Lopez-Verges, Sandra [1 ]
Torres-Cosme, Rolando [2 ]
Popov, Vsevolod [4 ,5 ]
Widen, Steven G. [6 ]
Wood, Thomas G. [6 ]
Weaver, Scott C. [4 ,5 ]
Caceres-Carrera, Lorenzo [2 ]
Vasilakis, Nikos [4 ,5 ]
Tesh, Robert B. [4 ,5 ]
机构
[1] Gorgas Mem Inst Hlth Studies, Dept Virol & Biotechnol Res, Panama City, Panama
[2] Gorgas Mem Inst Hlth Studies, Dept Med Entomol, Panama City, Panama
[3] Columbus Univ, Sch Med, Panama City, Panama
[4] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA
[5] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA
[6] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA
关键词
WEST NILE VIRUS; INSECT-SPECIFIC FLAVIVIRUS; FUSING AGENT VIRUS; CULEX FLAVIVIRUS; VECTOR COMPETENCE; CELL-LINE; TRANSMISSION; SEQUENCE; STRAIN; RNA;
D O I
10.4269/ajtmh.15-0117
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Viruses in the genus Flavivirus (family Flaviviridae) include many arthropod-borne viruses of public health and veterinary importance. However, during the past two decades an explosion of novel insect-specific flaviviruses (ISFs), some closely related to vertebrate pathogens, have been discovered. Although many flavivirus pathogens of vertebrates have been isolated from naturally infected mosquitoes in Panama, ISFs have not previously been reported from the country. This report describes the isolation and characterization of a novel ISF, tentatively named Mercadeo virus (MECDV), obtained from Culex spp. mosquitoes collected in Panama. Two MECDV isolates were sequenced and cluster phylogenetically with cell-fusing agent virus (CFAV) and Nakiwogo virus (NAKV) to form a distinct lineage within the insect-specific group of flaviviruses.
引用
收藏
页码:1014 / 1019
页数:6
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