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T cell selection and autoimmunity: Flexibility and tuning

被引：50
作者：
Ohashi, PS [1 ]
机构：
[1] ONTARIO CANC INST,DEPT IMMUNOL,TORONTO,ON M5G 2M9,CANADA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(96)80009-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Peptide-MHC interactions govern the fate of T cells in the thymus and the peripheral T cell repertoire. Recent progress has involved investigating how different peptides influence T cell selection and mature T cell function and the subsequent implications for tolerance and autoimmunity.
引用
收藏
页码：808 / 814
页数：7
相关论文
共 62 条
  • [1] T-cell-receptor affinity and thymocyte positive selection
    Alam, SM
    Travers, PJ
    Wung, JL
    Nasholds, W
    Redpath, S
    Jameson, SC
    Gascoigne, NRJ
    [J]. NATURE, 1996, 381 (6583) : 616 - 620
  • [2] PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS
    ASHTONRICKARDT, PG
    VANKAER, L
    SCHUMACHER, TNM
    PLOEGH, HL
    TONEGAWA, S
    [J]. CELL, 1993, 73 (05) : 1041 - 1049
  • [3] EVIDENCE FOR A DIFFERENTIAL AVIDITY MODEL OF T-CELL SELECTION IN THE THYMUS
    ASHTONRICKARDT, PG
    BANDEIRA, A
    DELANEY, JR
    VANKAER, L
    PIRCHER, HP
    ZINKERNAGEL, RM
    TONEGAWA, S
    [J]. CELL, 1994, 76 (04) : 651 - 663
  • [4] PEPTIDE ANTAGONISTS THAT PROMOTE POSITIVE SELECTION ARE INEFFICIENT AT T-CELL ACTIVATION AND THYMOCYTE DELETION
    BARNDEN, MJ
    HEATH, WR
    RODDA, S
    CARBONE, FR
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) : 2452 - 2456
  • [5] BHARDWAJ V, 1993, J IMMUNOL, V151, P5000
  • [6] PEPTIDE BINDING TO CLASS-I MHC ON LIVING CELLS AND QUANTITATION OF COMPLEXES REQUIRED FOR CTL LYSIS
    CHRISTINCK, ER
    LUSCHER, MA
    BARBER, BH
    WILLIAMS, DB
    [J]. NATURE, 1991, 352 (6330) : 67 - 70
  • [7] SPECIFIC T-CELL RECOGNITION OF MINIMALLY HOMOLOGOUS PEPTIDES - EVIDENCE FOR MULTIPLE ENDOGENOUS LIGANDS
    EVAVOLD, BD
    SLOANLANCASTER, J
    WILSON, KJ
    ROTHBARD, JB
    ALLEN, PM
    [J]. IMMUNITY, 1995, 2 (06) : 655 - 663
  • [8] LEVELS OF PERIPHERAL T-CELL TOLERANCE INDUCED BY DIFFERENT DOSES OF TOLEROGEN
    FERBER, I
    SCHONRICH, G
    SCHENKEL, J
    MELLOR, AL
    HAMMERLING, GJ
    ARNOLD, B
    [J]. SCIENCE, 1994, 263 (5147) : 674 - 676
  • [9] Antigen presentation and T cell development in H2-M-deficient mice
    FungLeung, WP
    Surh, CD
    Liljedahl, M
    Pang, J
    Leturcq, D
    Peterson, PA
    Webb, SR
    Karlsson, L
    [J]. SCIENCE, 1996, 271 (5253) : 1278 - 1281
  • [10] GARZA KM, 1995, J IMMUNOL, V155, P5444
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