eIF3-f function in skeletal muscles

被引:24
作者
Csibi, Alfredo [1 ]
Tintignac, Lionel A. [1 ]
Leibovitch, Marie Pierre [1 ]
Leibovitch, Serge A. [1 ]
机构
[1] INRA UM 2, Lab Genom Fonct & Myogenese, UMR Differenciat Cellulaire & Croissance 866, Montpellier, France
关键词
MAFbx/atrogin-1; eIF3-f; ubiquitin-proteasome; atrophy; hypertrophy;
D O I
10.4161/cc.7.12.6090
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The control of muscle cell size is a physiological process balanced by a fine tuning between protein synthesis and protein degradation. MAFbx/Atrogin-1 is a muscle specific E3 ubiquitin ligase upregulated during disuse, immobilization and fasting or systemic diseases such as diabetes, cancer, AIDS and renal failure. This response is necessary to induce a rapid and functional atrophy. To date, the targets of MAFbx/Atrogin-1 in skeletal muscle remain to be identified. We have recently presented evidence that eIF3-f, a regulatory subunit of the eukaryotic translation factor eIF3 is a key target that accounts for MAFbx/Atrogin-1 function in muscle atrophy. More importantly, we showed that eIF3-f acts as a "translational enhancer" that increases the efficiency of the structural muscle proteins synthesis leading to both in vitro and in vivo muscle hypertrophy. We propose that eIF3-f subunit, a mTOR/S6K1 scaffolding protein in the IGF-1/Akt/mTOR dependent control of protein translation, is a positive actor essential to the translation of specific mRNAs probably implicated in muscle hypertrophy. The central role of eIF3-f in both the atrophic and hypertrophic pathways will be discussed in the light of its promising potential in muscle wasting therapy.
引用
收藏
页码:1698 / 1701
页数:4
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