New sesquiterpene hydroquinones from a Taiwanese marine sponge Polyfibrospongia australis

被引：30

作者：

Shen, YC

Hsieh, PW

机构：

[1] Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, 80424

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 02期

关键词：

D O I：

10.1021/np9605302

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpene hydroquinones, polyfibrospongols A (1) and B (2), were isolated from the Taiwanese marine sponge Polyfibrospongia australis Lendenfeld (Spongiidae) in addition to the known metabolites, dictyoceratin A (3), ilimaquinone (4), and 5-epi-ilimaquinone (9). The structures of these compounds have been determined mainly on the basis of spectral and chemical methods. Biological testing revealed that compounds 1 and 2 exhibited significant cytotoxicity against human KB-16, A-549, and murine P-388 tumor cell lines.

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页码：93 / 97

页数：5

相关论文

共 16 条

[1]

Capon R. J., 1995, Stud. Nat. Prod. Chem, P289

[2] A REVISION OF THE ABSOLUTE STEREOCHEMISTRY OF ILIMAQUINONE [J].

CAPON, RJ ;

MACLEOD, JK .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (22) :5059-5060

[3] NEW AVARONE AND AVAROL DERIVATIVES FROM THE MARINE SPONGE DYSIDEA-CINEREA [J].

HIRSCH, S ;

RUDI, A ;

KASHMAN, Y ;

LOYA, Y .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (01) :92-97

[4] BIOLOGICALLY-ACTIVE QUINONE AND HYDROQUINONE SESQUITERPENOIDS FROM THE SPONGE SMENOSPONGIA SP [J].

KONDRACKI, ML ;

GUYOT, M .

TETRAHEDRON, 1989, 45 (07) :1995-2004

[5] METABOLITES OF THE PALAUAN SPONGE DACTYLOSPONGIA SP [J].

KUSHLAN, DM ;

FAULKNER, DJ ;

PARKANYI, L ;

CLARDY, J .

TETRAHEDRON, 1989, 45 (11) :3307-3312

[6] ILIMAQUINONE, A SESQUITERPENOID QUINONE FROM A MARINE SPONGE [J].

LUIBRAND, RT ;

ERDMAN, TR ;

VOLLMER, JJ ;

SCHEUER, PJ ;

FINER, J ;

CLARDY, J .

TETRAHEDRON, 1979, 35 (05) :609-612

[7]

MARCH J, 1973, ADV ORGANIC CHEM REA, P578

[8] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[9] PHYSIOLOGICALLY ACTIVE MARINE NATURAL-PRODUCTS FROM PORIFERA .14. DICTYOCERATIN-A AND DICTYOCERATIN-B, NOVEL ANTIMICROBIAL TERPENOIDS FROM THE OKINAWAN MARINE SPONGE HIPPOSPONGIA SP [J].

NAKAMURA, H ;

DENG, SZ ;

KOBAYASHI, J ;

OHIZUMI, Y ;

HIRATA, Y .

TETRAHEDRON, 1986, 42 (15) :4197-4201

[10] THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA-ELEGANS [J].

RODRIGUEZ, J ;

QUINOA, E ;

RIGUERA, R ;

PETERS, BM ;

ABRELL, LM ;

CREWS, P .

TETRAHEDRON, 1992, 48 (32) :6667-6680