Reactive oxygen species a double-edged sword for mesothelioma

被引:73
作者
Benedetti, Serena [1 ]
Nuvoli, Barbara [2 ]
Catalani, Simona [1 ]
Galati, Rossella [2 ]
机构
[1] Univ Urbino Carlo Bo, Dept Biomol Sci, Urbino, Italy
[2] Regina Elena Inst Canc Res, Mol Med Area, Rome, Italy
关键词
reactive oxygen species; mesothelioma; cell trasformation; cell proliferation; therapy; NF-KAPPA-B; MANGANESE SUPEROXIDE-DISMUTASE; GROWTH-FACTOR RECEPTOR; DNA-BINDING ACTIVITY; PROTEIN-KINASE-C; OXIDATIVE STRESS; MALIGNANT MESOTHELIOMA; CANCER-CELLS; NITRIC-OXIDE; LIPID-PEROXIDATION;
D O I
10.18632/oncotarget.4253
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
It is well known that oxidative stress can lead to chronic inflammation which, in turn, could mediate most chronic diseases including cancer. Oxidants have been implicated in the activity of crocidolite and amosite, the most powerful types of asbestos associated to the occurrence of mesothelioma. Currently rates of mesothelioma are rising and estimates indicate that the incidence of mesothelioma will peak within the next 10-15 years in the western world, while in Japan the peak is predicted not to occur until 40 years from now. Although the use of asbestos has been banned in many countries around the world, production of and the potentially hazardous exposure to asbestos is still present with locally high incidences of mesothelioma. Today a new man-made material, carbon nanotubes, has arisen as a concern; carbon nanotubes may display 'asbestos-like' pathogenicity with mesothelioma induction potential. Carbon nanotubes resulted in the greatest reactive oxygen species generation. How oxidative stress activates inflammatory pathways leading to the transformation of a normal cell to a tumor cell, to tumor cell survival, proliferation, invasion, angiogenesis, chemoresistance, and radioresistance, is the aim of this review.
引用
收藏
页码:16848 / 16865
页数:18
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