The interieukin-15/interieukin-15 receptor system as a model for juxtacrine and reverse signaling (Publication with Expression of Concern)

被引：55

作者：

Bulfone-Paus, S

Bulanova, E

Budagian, V

Paus, R

机构：

[1] Res Ctr Borstel, Dept Immunol & Cell Biol, D-23845 Borstel, Germany

[2] Med Univ Lubeck, Hosp Schleswig Holstein, Dept Dermatol, Lubeck, Germany

来源：

BIOESSAYS | 2006年 / 28卷 / 04期

关键词：

D O I：

10.1002/bies.20380

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-15 (IL-15) is a pleiotropic cytokine of the 4 alpha-helix bundle family, which binds to a receptor complex that displays common elements with the IL-2 receptor and a unique high-affinity a chain. This review focuses on juxtacrine and reverse signaling levels in the IL-15/IL-15R system. Specifically, we discuss how agonistic stimulation of membrane-bound IL-15 induces phosphorylation of members of the MAP kinase family and of focal adhesion kinase (FAK), thereby upregulating processes including cytokine secretion, cell adhesion and migration. In addition, we explore IL-15 trans-presentation and intracellular signaling, and define promising molecular targets for future pharmacological intervention in infectious diseases and immunological disorders. These frontiers in IL-15/IL-15R alpha research serve as highly instructive examples for key concepts, unsolved problems and therapeutic opportunities in juxtacrine and reverse signaling in general.

引用

页码：362 / 377

页数：16

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