Wistar-Imamichi rats exhibit a strong resistance to cadmium toxicity

被引：11

作者：

Shimada, H

Nagano, M

Yasutake, A

Imamura, Y

机构：

[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan

[2] Kumamoto Univ, Fac Educ, Kumamoto 8608555, Japan

[3] Natl Inst Minamata Dis, Kumamoto 8670008, Japan

来源：

JOURNAL OF HEALTH SCIENCE | 2002年 / 48卷 / 02期

关键词：

Wistar-Imamichi rat; cadmium toxicity; strain difference; metallothionein content;

D O I：

10.1248/jhs.48.201

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The strain difference in the toxicity of cadmium (Cd) was examined in male rats. All rats of the Wistar-Imamichi (Wistar-IM) strain survived for 7 days after treatment with Cd at a dose of 5.0 mg/kg body weight, whereas 80% of the Wistar strain and 100% of the Sprague-Dawley and Fischer strains died. These results indicate that the Wistar-IM strain has strong resistance to Cd. Furthermore, the metallothionein (MT) contents of the liver, kidney and testis of Wistar-IM rats were compared with those of Fischer rats. The strain difference in the toxicity of Cd in rats did not appear to result from a difference in MT content, although further study is necessary to elucidate the role of MT.

引用

页码：201 / 203

页数：3

共 16 条

[1]

[Anonymous], TOXICOLOGY METALS

[2] Strain difference (WKY, SPRD) in the hepatic antioxidant status in rat and effect of hypertension (SHR, DOCA).: Ex vivo and in vitro data [J].