Antimutagenicity, cytotoxicity and composition of chlorophyllin copper complex

被引:30
作者
Chernomorsky, S
Rancourt, R
Virdi, K
Segelman, A
Poretz, RD
机构
[1] RUTGERS STATE UNIV, DEPT MICROBIOL, NEW BRUNSWICK, NJ 08903 USA
[2] RUTGERS STATE UNIV, DEPT BIOL CHEM, NEW BRUNSWICK, NJ 08903 USA
[3] RUTGERS STATE UNIV, DEPT PHARMACOGNOSY, NEW BRUNSWICK, NJ 08903 USA
关键词
chlorophyllin; N-methyl-N'-nitro-N-nitrosoguanidine; 3-methylcholanthrene; antimutagenicity; cytotoxicity; composition;
D O I
10.1016/S0304-3835(97)00304-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct-and indirect-acting mutagens in the Salmonella assay and exhibits cytostatic and cytocidal effects toward myeloma cells. Data from elemental analyses, spectrophotometry and reversed-phase high-performance liquid chromatography indicate that CCC preparations generally used in antimutagenic/anticarcinogenic experiments are variable, complex mixtures of structurally distinct porphyrins lacking copper in some instances. This variability of the composition may be a cause for the differences reported for the tumor promotion activity of CCC. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:141 / 147
页数:7
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