Proposal of a novel diabetogenic mechanism involving the serpin PAI-1

被引：12

作者：

Griffiths, Sarah L. ^{[1
]}

Grainger, David J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Addenbrookes Hosp, Cambridge CB2 2QQ, England

来源：

BIOESSAYS | 2006年 / 28卷 / 06期

关键词：

D O I：

10.1002/bies.20418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic Syndrome is a cluster of risk factors (including obesity, hypertension and insulin resistance), which is associated with late-onset diabetes and coronary heart disease. Elevated levels of the protease inhibitor PAI-1 are well-known molecular markers of the Metabolic Syndrome. Here, however, we present a hypothesis that PAI-1 acts as a causative factor in the development of Metabolic Syndrome and its clinical sequelae. We propose that PAI-1 inhibits the activity of members of the proprotein convertase (PC) class of serine proteases and that this underlies, at a molecular level, many of the other features of the Metabolic Syndrome cluster.

引用

页码：629 / 641

页数：13

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