C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

被引：69

作者：

Ekthawatchai, S

Kamchonwongpaisan, S

Kongsaeree, P

Tarnchompoo, B

Thebtaranonth, Y

Yuthavong, Y

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[2] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Bangkok 10400, Thailand

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 26期

关键词：

D O I：

10.1021/jm0103007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grignard reagents to artemisitene provided C-16-derived artemisinin monomers, dimers, trimers, and tetramers whose antimalarial and cytotoxic activities have been evaluated.

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页码：4688 / 4695

页数：8

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