RETRACTED: Vitamin D levels do not predict cardiovascular events in statin-treated patients with stable coronary disease (Retracted article. See vol. 166, 2013)

被引:12
作者
Bittner, Vera [1 ]
Wenger, Nanette K. [2 ]
Waters, David D. [3 ]
DeMicco, David A. [4 ]
Messig, Michael [4 ]
LaRosa, John C. [5 ]
机构
[1] Univ Alabama Birmingham, Birmingham, AL 35294 USA
[2] Emory Univ, Atlanta, GA 30322 USA
[3] San Francisco Gen Hosp, San Francisco, CA 94110 USA
[4] Pfizer Inc, New York, NY USA
[5] SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA
关键词
NUTRITION EXAMINATION SURVEY; CHRONIC KIDNEY-DISEASE; 3RD NATIONAL-HEALTH; HYPOVITAMINOSIS-D; HEART-DISEASE; UNITED-STATES; RISK; 25-HYDROXYVITAMIN-D; PREVALENCE; ATORVASTATIN;
D O I
10.1016/j.ahj.2012.06.016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background This post hoc nested case-control analysis of the TNT study was designed to investigate whether baseline vitamin D level is a significant predictor of cardiovascular risk among statin-treated patients and whether changes in vitamin D after treatment with atorvastatin are associated with improved cardiovascular outcomes. Methods A total of 10,001 patients with stable coronary heart disease were randomized to atorvastatin 80 or 10 mg for a median of 4.9 years. This analysis included 1,509 patients (497 with a subsequent cardiovascular event and 1,012 without an event) with vitamin D levels determined at baseline and 1 year. Event rates were analyzed by Cox proportional hazard model by baseline vitamin D levels, with vitamin D as a continuous variable, and with change in vitamin D level as the predictor. Results Vitamin D deficiency (<15 ng/mL) or insufficiency (15-<30 ng/mL) was present in 108 (7.2%) of 1,509 and 625 (41.4%) of 1,509 of patients, whereas 46 (3.0%) of 1,509 had elevated vitamin D. There was no relationship between baseline vitamin D levels or change in vitamin D levels and cardiovascular events or mortality. Modeling of events with vitamin D as a continuous variable similarly showed no relationship of vitamin D to events. These findings held true after adjustment for seasonal variations in vitamin D and other confounders. Conclusion In statin-treated patients with stable coronary heart disease, vitamin D levels did not predict cardiovascular risk. Changes in plasma concentrations of vitamin D after 1 year of treatment made no contribution to the efficacy of atorvastatin therapy. (Am Heart J 2012;164:387-93.)
引用
收藏
页码:387 / 393
页数:7
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