The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response

被引：94

作者：

Cook, GA

Familari, M

Thim, L

Giraud, AS ^{[1
]}

机构：

[1] Univ Melbourne, Dept Med, Western Hosp, Footscray, Vic 3011, Australia

[2] Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark

来源：

FEBS LETTERS | 1999年 / 456卷 / 01期

基金：

英国医学研究理事会;

关键词：

trefoil factor; lymphoid tissue; inflammatory response;

D O I：

10.1016/S0014-5793(99)00940-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the trefoil factor (TFF) family are mucin-associated polypeptides that are expressed along the entire length of the gastrointestinal tract. TFFs have been proposed to play a role in mucosal defence through both protective and reparative mechanisms. The potential relationship between TFFs and mucins in non-gut glycoprotein-secreting epithelia has not been fully explored. In the present study we identified TFF2 and TFF3 mRNA and peptide in rat lymphoid tissues, demonstrated that TFF peptide expression in rat spleen increased 1.5- to 3-fold following experimental induction of the immune response, and showed that hTFF2 and hTFF3 (1-5 mg/ml) stimulated migration of human monocytes, Our data suggest that TFFs may in part be involved in the repair of injury through the modulation of the inflammatory response. (C) 1999 Federation of European Biochemical Societies.

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收藏

页码：155 / 159

页数：5

相关论文

共 30 条

[1] Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats [J].

Babyatsky, MW ;

deBeaumont, M ;

Thim, L ;

Podolsky, DK .

GASTROENTEROLOGY, 1996, 110 (02) :489-497

[2] LOCALIZATION OF INTESTINAL TREFOIL-FACTOR MESSENGER-RNA IN RAT STOMACH AND INTESTINE BY HYBRIDIZATION INSITU [J].

CHINERY, R ;

POULSOM, R ;

ROGERS, LA ;

JEFFERY, RE ;

LONGCROFT, JM ;

HANBY, AM ;

WRIGHT, NA .

BIOCHEMICAL JOURNAL, 1992, 285 :5-8

[3]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[4] Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats [J].

Cook, GA ;

Thim, L ;

Yeomans, ND ;

Giraud, AS .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 13 (04) :363-370

[5] Temporal expression of trefoil peptides in the TGF-alpha knockout mouse after gastric ulceration [J].

Cook, GA ;

Yeomans, ND ;

Giraud, AS .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 272 (06) :G1540-G1549

[6] TREFOIL PEPTIDES PROMOTE EPITHELIAL MIGRATION THROUGH A TRANSFORMING GROWTH-FACTOR BETA-INDEPENDENT PATHWAY [J].

DIGNASS, A ;

LYNCHDEVANEY, K ;

KINDON, H ;

THIM, L ;

PODOLSKY, DK .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :376-383

[7] Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells [J].

Efstathiou, JA ;

Noda, M ;

Rowan, A ;

Dixon, C ;

Chinery, R ;

Jawhari, A ;

Hattori, T ;

Wright, NA ;

Bodmer, WF ;

Pignatelli, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3122-3127

[8] PANCREATIC SPASMOLYTIC POLYPEPTIDE - FIRST 3-DIMENSIONAL STRUCTURE OF A MEMBER OF THE MAMMALIAN TREFOIL FAMILY OF PEPTIDES [J].

GAJHEDE, M ;

PETERSEN, TN ;

HENRIKSEN, A ;

PETERSEN, JFW ;

DAUTER, Z ;

WILSON, KS ;

THIM, L .

STRUCTURE, 1993, 1 (04) :253-262

[9] SPASMOLYTIC POLYPEPTIDE IS A MAJOR ANTRAL PEPTIDE - DISTRIBUTION OF THE TREFOIL PEPTIDES HUMAN SPASMOLYTIC POLYPEPTIDE AND PS2 IN THE STOMACH [J].

HANBY, AM ;

POULSOM, R ;

SINGH, S ;

ELIA, G ;

JEFFERY, RE ;

WRIGHT, NA .

GASTROENTEROLOGY, 1993, 105 (04) :1110-1116

[10] PS2 GENE ESPECIALLY EXPRESSED IN THE LATE G(1)/S PHASE OF MOUSE ASTROCYTES [J].

HIROTA, M ;

MIYASHITA, S ;

HAYASHI, H ;

FURUKAWA, Y ;

HAYASHI, K .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :49-51