Intrauterine programming of physiological systems: Causes and consequences

被引：386

作者：

Fowden, AL ^{[1
]}

Giussani, DA ^{[1
]}

Forhead, AJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol, Cambridge, England

来源：

PHYSIOLOGY | 2006年 / 21卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1152/physiol.00050.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnormalities in adult cardiovascular and metabolic function in several species. The timing, duration, severity, and type of insult during development determines the specific physiological outcome. Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age.

引用

页码：29 / 37

页数：9

共 57 条

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