Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis:: Results of a double-blind, placebo-controlled 3-year study

被引：90

作者：

McCloskey, E ^{[1
]}

Selby, P ^{[1
]}

Davies, M ^{[1
]}

Robinson, J ^{[1
]}

Francis, RM ^{[1
]}

Adams, J ^{[1
]}

Kayan, K ^{[1
]}

Beneton, M ^{[1
]}

Jalava, TI ^{[1
]}

Pylkkänen, L ^{[1
]}

Kenraali, J ^{[1
]}

Aropuu, S ^{[1
]}

Kanis, JA ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med, World Hlth Org Collaborating Ctr Matab Bone Dis, Div Genom Med, Sheffield S10 2RX, S Yorkshire, England

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

osteoporosis; clodronate; vertebral fracture; nonvertebral fracture;

D O I：

10.1359/JBMR.040116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The efficacy of oral clodronate 800 mg daily to reduce vertebral fractures was studied in 593 women with postmenopausal or secondary osteoporosis. The incidence of vertebral fractures was significantly reduced by 46%. The effect was not modified by the underlying cause of osteoporosis or other baseline factors including bone mineral density, QUS, weight, and smoking.

引用

页码：728 / 736

页数：9

共 38 条

[1] Fracture risk reduction with alendronate in women with osteoporosis: The Fracture Intervention Trial [J].

Black, DM ;

Thompson, DE ;

Bauer, DC ;

Ensrud, K ;

Musliner, T ;

Hochberg, MC ;

Nevitt, MC ;

Suryawanshi, S ;

Cummings, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (11) :4118-4124

[2] Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].

Black, DM ;

Cummings, SR ;

Karpf, DB ;

Cauley, JA ;

Thompson, DE ;

Nevitt, MC ;

Bauer, DC ;

Genant, HK ;

Haskell, WL ;

Marcus, R ;

Ott, SM ;

Torner, JC ;

Quandt, SA ;

Reiss, TF ;

Ensrud, KE .

LANCET, 1996, 348 (9041) :1535-1541

[3] Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs [J].

Cummings, SR ;

Karpf, DB ;

Harris, F ;

Genant, HK ;

Ensrud, K ;

LaCroix, AZ ;

Black, DM .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (04) :281-289

[4] Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].

Cummings, SR ;

Black, DM ;

Thompson, DE ;

Applegate, WB ;

Barrett-Connor, E ;

Musliner, TA ;

Palermo, L ;

Prineas, R ;

Rubin, SM ;

Scott, JC ;

Vogt, T ;

Wallace, R ;

Yates, AJ ;

LaCroix, AZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082

[5] Esophagitis associated with the use of alendronate [J].

deGroen, PC ;

Lubbe, DF ;

Hirsch, LJ ;

Daifotis, A ;

Stephenson, W ;

Freedholm, D ;

PryorTillotson, S ;

Seleznick, MJ ;

Pinkas, H ;

Wang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (14) :1016-1021

[6] Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: Four-year results from a randomized clinical trial [J].

Delmas, PD ;

Ensrud, KE ;

Adachi, JD ;

Harper, KD ;

Sarkar, S ;

Gennari, C ;

Reginster, JY ;

Pols, HAP ;

Recker, RR ;

Harris, ST ;

Wu, WT ;

Genant, HK ;

Black, DM ;

Eastell, R .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (08) :3609-3617

[7] Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene -: Results from a 3-year randomized clinical trial [J].

Ettinger, B ;

Black, DM ;

Mitlak, BH ;

Knickerbocker, RK ;

Nickelsen, T ;

Genant, HK ;

Christiansen, C ;

Delmas, PD ;

Zanchetta, JR ;

Stakkestad, J ;

Glüer, CC ;

Krueger, K ;

Cohen, FJ ;

Eckert, S ;

Ensrud, KE ;

Avioli, LV ;

Lips, P ;

Cummings, SR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07) :637-645

[8] Cyclical intravenous clodronate in postmenopausal osteoporosis: Results of a long-term clinical trial [J].

Filipponi, P ;

Cristallini, S ;

Rizzello, E ;

Policani, G ;

Fedeli, L ;

Gregorio, F ;

Boldrini, S ;

Troiani, S ;

Massoni, C .

BONE, 1996, 18 (02) :179-184

[9] Continuous and cyclical clodronate therapies and bone density in postmenopausal bone loss [J].

Giannini, S ;

DAngelo, A ;

Sartori, L ;

Passeri, G ;

Carbonare, LD ;

Crepaldi, G .

OBSTETRICS AND GYNECOLOGY, 1996, 88 (03) :431-436

[10] EFFECTS OF ONE-YEAR CYCLICAL TREATMENT WITH CLODRONATE ON POSTMENOPAUSAL BONE LOSS [J].

GIANNINI, S ;

DANGELO, A ;

MALVASI, L ;

CASTRIGNANO, R ;

PATI, T ;

TRONCA, R ;

LIBERTO, L ;

NOBILE, M ;

CREPALDI, G .

BONE, 1993, 14 (02) :137-141

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