A highly efficient synthesis of the antiviral agent (+)-cyclaradine involving the regioselective cleavage of epoxide by neighboring participation

被引：21

作者：

Katagiri, N

Matsuhashi, Y

Kokufuda, H

Takebayashi, M

Kaneko, C

机构：

[1] Pharmaceutical Institute, Tohoku University, Sendai 980-77, Aobayama, Aoba-ku

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(97)00234-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-Cyclaradine, carbocyclic arabinofuranosyladenine having anti-HSV activity, has been synthesized from (-)-2-azabicyclo[2.2.1]hept-5-en-3-one in only seven steps. The method involves the novel ring cleavage of epoxide by neighboring participation. (C) 1997 Elsevier Science Ltd.

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页码：1961 / 1964

页数：4

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