Oxindole alkaloids. A novel non-biomimetic entry to (-)-horsfiline

被引：113

作者：

Palmisano, G ^{[1
]}

Annunziata, R ^{[1
]}

Papeo, G ^{[1
]}

Sisti, M ^{[1
]}

机构：

[1] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20135 MILAN,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 01期

关键词：

D O I：

10.1016/0957-4166(95)00406-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel non-biomimetic synthesis of horsfiline has been developed. The key pyrrolidine forming reaction is the 1,3-dipolar cycloaddition of the thermally generated N-methylazomethine ylide to a suitable 3-alkylidene-indolin-2(3H)one. The same strategy was also applied to the synthesis of pure (R)-(-)-enantiomer.

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页码：1 / 4

页数：4

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