Elderly immune response to a TI-2 antigen:: Heavy and light chain use and bactericidal activity to Neisseria meningitidis serogroup C polysaccharide

被引:14
作者
Hutchins, WA
Carlone, GM
Westerink, MAJ
机构
[1] Med Coll Ohio, Dept Med, Toledo, OH 43699 USA
[2] Med Coll Ohio, Dept Pathol, Toledo, OH 43699 USA
[3] Ctr Dis Control, Resp Dis Branch, Div Bacterial & Mycot Dis, Atlanta, GA 30333 USA
关键词
D O I
10.1086/314750
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previous studies of the elderly immune response to TI-2 antigens failed to correlate specific antibody levels with function and to compare responses with those of young adults. Neisseria meningitidis serogroup C capsular polysaccharide (MCPS) was used as a model TI-2 antigen. Anti-MCPS antibody levels were determined in elderly individuals and correlated with bactericidal activity. The anti-MCPS response in most persons was characterized by predominant IgG usage, with IgG2 > IgG1, No light chain or IgA subclass predominated, but some responses showed a particular chain type, Bactericidal activity correlated best with IgG2 levels. Elderly subjects had lower anti-MCPS responses than the young adults did in all chain-specific anti-MCPS levels, and levels declined more rapidly. Bactericidal activity following immunization was significantly lower in the elderly persons. These results suggest the anti-MCPS antibody repertoire in the elderly is likely maintained, and the lower level of function is related to the lower antibody levels.
引用
收藏
页码:1433 / 1440
页数:8
相关论文
共 63 条
[1]   COMPARISON AMONG OPSONIC ACTIVITY, ANTIMENINGOCOCCAL IMMUNOGLOBULIN-G RESPONSE, AND SERUM BACTERICIDAL ACTIVITY AGAINST MENINGOCOCCI IN SERA FROM VACCINEES AFTER IMMUNIZATION WITH A SEROGROUP-B OUTER-MEMBRANE VESICLE VACCINE [J].
AASE, A ;
BJUNE, G ;
HOIBY, EA ;
ROSENQVIST, E ;
PEDERSEN, AK ;
MICHAELSEN, TE .
INFECTION AND IMMUNITY, 1995, 63 (09) :3531-3536
[2]   OPSONOPHAGOCYTIC ACTIVITY-INDUCED BY CHIMERIC ANTIBODIES OF THE 4 HUMAN-IGG SUBCLASSES WITH OR WITHOUT HELP FROM COMPLEMENT [J].
AASE, A ;
MICHAELSEN, TE .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1994, 39 (06) :581-587
[3]   AGE-ASSOCIATED IMPAIRMENT OF MURINE NATURAL-KILLER ACTIVITY [J].
ALBRIGHT, JW ;
ALBRIGHT, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6371-6375
[4]   T-CELLS AND NATURAL-KILLER-CELLS REGULATE HUMAN-IGG SUBCLASS CONCENTRATIONS IN SCID MICE [J].
AMBROSINO, DM ;
WANG, M ;
CIAMARRA, A ;
CHAN, M ;
BOLON, DL ;
MINN, J ;
JACOBSOHN, DA ;
FINBERG, RW .
CELLULAR IMMUNOLOGY, 1994, 155 (01) :134-143
[5]   CORRELATION OF THE KM(1) IMMUNOGLOBULIN ALLOTYPE WITH ANTI-POLYSACCHARIDE ANTIBODIES IN CAUCASIAN ADULTS [J].
AMBROSINO, DM ;
BARRUS, VA ;
DELANGE, GG ;
SIBER, GR .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (02) :361-365
[6]   BACTERICIDAL AND OPSONIC ACTIVITY OF IGG1 AND IGG2 ANTICAPSULAR ANTIBODIES TO HAEMOPHILUS-INFLUENZAE TYPE-B [J].
AMIR, J ;
SCOTT, MG ;
NAHM, MH ;
GRANOFF, DM .
JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (01) :163-171
[7]  
AMMANN AJ, 1980, P SOC EXP BIOL MED, V164, P312
[8]  
[Anonymous], 1997, MORTALITY WEEKLY REP
[9]   HEAVY-CHAIN ISOTYPE PATTERNS OF HUMAN ANTIBODY-SECRETING CELLS INDUCED BY HAEMOPHILUS-INFLUENZAE TYPE-B CONJUGATE VACCINES IN RELATION TO AGE AND PREIMMUNITY [J].
BARINGTON, T ;
JUUL, L ;
GYHRS, A ;
HEILMANN, C .
INFECTION AND IMMUNITY, 1994, 62 (08) :3066-3074
[10]  
BARRETT DJ, 1986, CLIN EXP IMMUNOL, V63, P127