Contrast-enhanced MR imaging of the liver: Comparison between Gd-BOPTA and Mangafodipir

被引:24
作者
Schima, W [1 ]
Petersein, J [1 ]
Hahn, PF [1 ]
Harisinghani, M [1 ]
Halpern, E [1 ]
Saini, S [1 ]
机构
[1] MASSACHUSETTS GEN HOSP,DEPT RADIOL,BOSTON,MA 02114
来源
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1997年 / 7卷 / 01期
关键词
contrast media; effects; liver; MR; contrast enhancement; gadolinium; manganese;
D O I
10.1002/jmri.1880070118
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of the study was to evaluate the MR contrast agents gadolinium benzyloxypropionictetro-acetate (Gd-BOPTA) and Mangafodipir for liver enhancement and the lesion-liver contrast on T1W spin-echo (SE) and gradient-recalled-echo (GRE) images, Fifty-one patients (three groups of 17 patients each) with known or suspected liver lesions were evaluated with T1W SE (300/12) and GRE (77-80/2.3-2.5/80 degrees) images before and after intravenous (IV) Gd-BOPTA (0.1 or 0.05 mmol/kg) or Mangafodipir (5 mu mol/kg) in phase II to III clinical trials. Quantitative analysis by calculating liver signal-to-noise ratio (SNR), lesion-liver contrast-to-noise ratio (CNR), and spleen-liver CNR was performed, Liver SNR and spleen-liver CNR were always significantly increased postcontrast. SNR was highest after application of 0.1 mmol/kg Gd-BOPTA (51.3 +/- 3.6, P < .05). CNR was highest after Mangafodipir (-22.6 +/- 2.7), but this was not significantly different from others (P = .07). Overall, GRE images were superior to SE images for SNR and CNR, Mangafodipir and Gd-BOPTA (0.1 mmol/kg) provide equal liver enhancement and lesion conspicuity postcontrast. By all criteria, contrast-enhanced T1-weighted GRE were comparable to SE images.
引用
收藏
页码:130 / 135
页数:6
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