Calcification and endothelialization of thrombi in acute stroke

被引：67

作者：

Almekhlafi, Mohammed A. ^{[2
]}

Hu, William Y. ^{[3
]}

Hill, Michael D. ^{[2
,4
,5
]}

Auer, Roland N. ^{[1
]}

机构：

[1] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Dept Diagnost Imaging, Calgary, AB T2N 4N1, Canada

[4] Univ Calgary, Dept Med, Calgary, AB T2N 4N1, Canada

[5] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 4N1, Canada

来源：

ANNALS OF NEUROLOGY | 2008年 / 64卷 / 03期

关键词：

D O I：

10.1002/ana.21404

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report chronic histopathological features in thrombi mechanically retrieved from five acute ischemic stroke patients with a median age of 68 years and a median pretreatment National Institutes of Health Stroke Scale score of 13. Early endothelialization occurred over and within the thrombus, and calcifications were seen, in addition to the usual acute laminar fibrin, intervening red blood cells, and neutrophils. The effectiveness of tissue plasminogen activator in clot dissolution might be affected by these features, if extensive. Thrombus composition could critically determine the success of chemical thrombolysis. Our results should stimulate the development of imaging modalities to determine thrombus composition.

引用

页码：344 / 348

页数：5

共 15 条

[1] Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy
Barber, PA
Demchuk, AM
Zhang, JJ
Buchan, AM
[J]. LANCET, 2000, 355 (9216) : 1670 - 1674
[2] RECOMBINANT TISSUE PLASMINOGEN-ACTIVATOR IN ACUTE THROMBOTIC AND EMBOLIC STROKE
DELZOPPO, GJ
POECK, K
PESSIN, MS
WOLPERT, SM
FURLAN, AJ
FERBERT, A
ALBERTS, MJ
ZIVIN, JA
WECHSLER, L
BUSSE, O
GREENLEE, R
BRASS, L
MOHR, JP
FELDMANN, E
HACKE, W
KASE, CS
BILLER, J
GRESS, D
OTIS, SM
[J]. ANNALS OF NEUROLOGY, 1992, 32 (01) : 78 - 86
[3] The Food and Drug Administration medical device review process -: Clearance of a clot retriever for use in ischemic stroke
Felten, RP
Ogden, NRP
Peña, C
Provost, MC
Schlosser, MJ
Witten, CM
[J]. STROKE, 2005, 36 (02) : 404 - 406
[4] INTERPHYSICIAN AGREEMENT IN THE DIAGNOSIS OF SUBTYPES OF ACUTE ISCHEMIC STROKE - IMPLICATIONS FOR CLINICAL-TRIALS
GORDON, DL
BENDIXEN, BH
ADAMS, HP
CLARKE, W
KAPPELLE, LJ
WOOLSON, RF
KASE, CS
WOLF, PA
BABIKIAN, VL
LICATAGEHR, EE
ALLEN, N
BRASS, LM
FAYAD, PB
PAVALKIS, FJ
WEINBERGER, JM
TUHRIM, S
RUDOLPH, SH
HOROWITZ, DR
BITTON, A
MOHR, JP
SACCO, RL
CLAVIJO, M
ROSENBAUM, DM
SPARR, SA
KATZ, P
KLONOWSKI, E
CULEBRAS, A
CAREY, G
MARTIR, NI
FICARRA, C
HOGAN, EL
CARTER, T
GURECKI, P
MUNTZ, BK
RAMIREZLASSEPAS, M
TULLOCH, JW
QUINONES, MR
MENDEZ, M
ZHANG, SM
ALA, T
JOHNSTON, KC
ANDERSON, DC
TARREL, RM
NANCE, MA
BUNDLIE, SR
DIERICH, M
HELGASON, CM
HIER, DB
SHAPIRO, RA
BRINT, S
[J]. NEUROLOGY, 1993, 43 (05) : 1021 - 1027
[5] Unsuccessful tissue plasminogen activator treatment of acute stroke caused by a calcific embolus
Halloran, JI
Bekavac, I
[J]. JOURNAL OF NEUROIMAGING, 2004, 14 (04) : 385 - 387
[6] Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke
Higashida, RT
Furlan, AJ
[J]. STROKE, 2003, 34 (08) : E109 - E137
[7] Revascularization end points in stroke interventional trials - Recanalization versus reperfusion in IMS-I
Khatri, P
Neff, J
Broderick, JP
Khoury, JC
Carrozzella, J
Tomsick, T
[J]. STROKE, 2005, 36 (11) : 2400 - 2403
[8] Kirchhof K, 2004, ROFO-FORTSCHR RONTG, V176, P98
[9] KUMAR R, 1995, THROMB HAEMOSTASIS, V74, P962
[10] Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke
Marder, Victor J.
Chute, Dennis J.
Starkman, Sidney
Abolian, Anna M.
Kidwell, Chelsea
Liebeskind, David
Ovbiagele, Bruce
Vinuela, Fernando
Duckwiler, Gary
Jahan, Reza
Vespa, Paul M.
Selco, Scott
Rajajee, Venkatakrishna
Kim, Dojin
Sanossian, Nerses
Saver, Jeffrey L.
[J]. STROKE, 2006, 37 (08) : 2086 - 2093

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