Role of T cells in the modulation of PTH action: physiological and clinical significance

被引：45

作者：

Pacifici, Roberto ^{[1
,2
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA

[2] Emory Univ, Immunol & Mol Pathogenesis Program, Atlanta, GA 30322 USA

来源：

ENDOCRINE | 2013年 / 44卷 / 03期

关键词：

T cells; PTH; Estrogen; Osteoimmunology; Bone; HEMATOPOIETIC STEM-CELLS; INCREASES BONE-FORMATION; PARATHYROID-HORMONE; DIFFERENTIATED OSTEOBLASTS; ANABOLIC ACTIVITY; PROGENITOR CELLS; BETA-CATENIN; RECEPTOR; GENE; PROLIFERATION;

D O I：

10.1007/s12020-013-9960-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Osteoimmunology is new field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone and hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells, one of which is Wnt10b. This article will review the evidence that T cells are implicated in the mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.

引用

收藏

页码：576 / 582

页数：7

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