The X-ray contrast medium iodixanol detects increased colonic permeability equally well as Cr-51-labeled ethylenediaminetetraacetic acid in experimental colitis of rats

被引:5
作者
Andersen, R
Hosaka, J
Halstensen, TS
Stordahl, A
Tverdal, A
Aabakken, L
Laerum, F
机构
[1] NATL HOSP NORWAY, INST SURG RES, N-0027 OSLO, NORWAY
[2] NATL HOSP NORWAY, INST PATHOL, LIIPAT, N-0027 OSLO, NORWAY
[3] NORWEGIAN COLL VET MED, OSLO, NORWAY
[4] UNIV OSLO, ULLEVAL HOSP, DEPT MED, OSLO, NORWAY
[5] RES COUNCIL NORWAY, OSLO, NORWAY
关键词
colitis; contrast media; experimental; Cr-51-ethylenediaminetetraacetic acid; intestines; iodixanol; permeability; rats; urinary excretion;
D O I
10.3109/00365529609031978
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Non-ionic, water-soluble radiographic contrast media have been suggested as intestinal permeability probes. We studied the permeability of the isosmolar contrast medium iodixanol and Cr-51-labeled ethylenediaminetetraacetic acid (EDTA) from the non-perforated colon after induction of colonic inflammation. Methods: Colonic inflammation and ulcerations were induced by luminal colonic instillation of trinitrobenzenesulfonic acid, dissolved in 40% ethanol. Controls received saline. Fourteen days later iodixanol, 320 mg I/ml, and Cr-51-EDTA were given as an enema. Urine was collected for the subsequent 6 h and subjected to high-performance liquid chromatography and gamma activity counting. Results: Urinary recovery of iodixanol and Cr-51-EDTA increased gradually with severity of the colonic inflammation. The correlation between iodixanol and Cr-51-EDTA recovery was strong (corr.coeff. = 0.97). Conclusions: Iodixanol shows as good properties as Cr-51-EDTA when used as intestinal permeability probe in the inflamed and ulcerated rat colon. Use of the radiopaque properties of iodixanol enable intestinal probe exposure registration by film or fluoroscopy.
引用
收藏
页码:140 / 146
页数:7
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