A case of isodicentric 7p as sole abnormality in a patient with acute myeloid leukemia

被引:13
作者
Beverstock, GC
deMeijer, PHEM
Huinink, DT
Pruijt, JFM
denOttolander, GJ
Wessels, HW
Mollevanger, P
机构
[1] UNIV LEIDEN HOSP, DEPT GEN INTERNAL MED, NL-2333 AL LEIDEN, NETHERLANDS
[2] UNIV LEIDEN HOSP, DEPT HEMATOL, NL-2333 AL LEIDEN, NETHERLANDS
关键词
D O I
10.1016/0165-4608(95)00316-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The detection of isochromosomes in the leukemias and in solid tumors has been well described in the literature, the most common being the i(17q), which is found in the blast crisis of CML and terminal stages of acute myeloid leukemia. Reports of isochromosome 7 have, how ever, been less well represented, particularly isochromosomes of the short arm of chromosome 7, which represent approximately 1% of all reported isochromosomes in neoplasia. We present here a case report of an elderly female patient with AML-M2 who manifested an idic(7p) in the majority of her bone marrow cells. Fluorescence in situ hybridization (FISH) studies with bath centromere-7-and chromosome-7-specific DNA probes verified the diagnosis of idic(7p). To the best of our knowledge, this is the first report of this type of leukemia with an acquired idic(7p) as the sole cytogenetic abnormality.
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页码:132 / 135
页数:4
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