Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

被引：58

作者：

Liu, Y

Xu, YF ^{[1
]}

Qian, XH

Liu, JW

Shen, LY

Li, JH

Zhang, YX

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 09期

基金：

中国国家自然科学基金;

关键词：

fluorescent markets; hypoxic cells; naphthalimides; bioreductive binding; 2-nitroimidazole;

D O I：

10.1016/j.bmc.2005.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried Out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A(2) and A(4) showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：2935 / 2941

页数：7

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