Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells

被引：43

作者：

Wang, Nan ^{[1
]}

Wang, Li-Wen ^{[2
]}

Gou, Bao-Di ^{[1
]}

Zhang, Tian-Lan ^{[1
,2
]}

Wang, Kui ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

[2] Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2008年 / 32卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Realgar; Arsenic sulfide; Differentiation; MAPK pathway; HL-60;

D O I：

10.1016/j.cellbi.2008.08.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The clinical efficacy and safety of realgar (arsenic sulfide, As4S4) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL-60 cells. Treatment with RNPs at 6 mu M for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP-induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP-induced differentiation in HL-60 cells. (c) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：1497 / 1505

页数：9

共 43 条

[1]

PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].