Structural aspects of heterotrimeric G-protein signaling

被引：72

作者：

Bohm, A ^{[1
]}

Gaudet, R ^{[1
]}

Sigler, PB ^{[1
]}

机构：

[1] YALE UNIV, HOWARD HUGHES MED INST, NEW HAVEN, CT 06511 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0958-1669(97)80072-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, structures of heterotrimeric G-protein subunits have been determined in isolation, in conjunction with each other, and in complex with their regulators. Along with biochemical information, these structures suggest how G-protein subunits are oriented relative to the membrane surface and relative to seven-transmembrane helix receptors. They also suggest mechanisms for receptor-catalyzed nucleotide exchange.

引用

页码：480 / 487

页数：8

共 52 条

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