Costimulatory regulation of T cell function

被引：331

作者：

Chambers, CA ^{[1
]}

Allison, JP ^{[1
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Res Inst, Canc Res Lab, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80027-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 entrances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.

引用

页码：203 / 210

页数：8

共 82 条

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