Altered Circadian Rhythm of Melatonin Concentrations in Hypocretin-Deficient Men

被引：11

作者：

Donjacour, Claire E. H. M. ^{[1
]}

Kalsbeek, Andries ^{[3
,4
]}

Overeem, Sebastiaan ^{[5
,6
]}

Lammers, Gert Jan ^{[1
]}

Pevet, Paul ^{[7
]}

Bothorel, Beatrice ^{[7
]}

Pijl, Hanno ^{[2
]}

Aziz, N. Ahmad ^{[1
]}

机构：

[1] Leiden Univ, Dept Neurol, Med Ctr, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Dept Endocrinol, Med Ctr, NL-2300 RC Leiden, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1105 AZ Amsterdam, Netherlands

[4] Netherlands Inst Neurosci, Amsterdam, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Donders Inst Neurosci, Dept Neurol, NL-6525 ED Nijmegen, Netherlands

[6] Sleep Med Ctr Kempenhaeghe, Heeze, Netherlands

[7] Inst Neurosci Integrat & Cellulaires, Dept Neurobiol Rythmes, Strasbourg, France

来源：

CHRONOBIOLOGY INTERNATIONAL | 2012年 / 29卷 / 03期

关键词：

Diurnal rhythm; GHB; Narcolepsy; Orexin; Polysomnography; Sodium oxybate; SALIVARY MELATONIN; SERUM CONCENTRATION; PINEAL-GLAND; OREXIN; SLEEP; NARCOLEPSY; TEMPERATURE; SECRETION; NEURONS; LIGHT;

D O I：

10.3109/07420528.2012.655869

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypocretin deficiency causes narcolepsy. It is unknown whether melatonin secretion is affected in this sleep disorder. Therefore, in both narcolepsy patients and matched controls, the authors measured plasma melatonin levels hourly for 24 h before and after 5 days of sodium oxybate (SXB) administration. Although mean melatonin concentrations were similar between patients and controls, in narcoleptics the percentage of 24-h melatonin secreted during the daytime was significantly higher, and melatonin secretion exhibited a weaker coupling to sleep. SXB did not affect melatonin secretion. These findings suggest that hypocretin deficiency might disturb both the circadian control of melatonin release and its temporal association with sleep. (Author correspondence: c.e.h.m.donjacour@lumc.nl)

引用

页码：356 / 362

页数：7

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