Adenosine receptors:: therapeutic aspects for inflammatory and immune diseases

被引：945

作者：

Hasko, Gyorgy ^{[1
]}

Linden, Joel ^{[2
,3
]}

Cronstein, Bruce ^{[4
]}

Pacher, Pal ^{[5
]}

机构：

[1] Univ Med & Dent New Jersey, Dept Surg, New Jersey Med Sch, Newark, NJ 07103 USA

[2] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA

[3] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

[4] NYU, Sch Med, Dept Med, New York, NY 10016 USA

[5] NIAAA, Sect Oxidat Stress Tissue Injury, Lab Physiol Studies, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd2638

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A(1), A(2A), A(2B) and A(3). Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.

引用

页码：759 / 770

页数：12

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