Spinal Cord Injury Pain: Mechanisms and Management

被引:140
作者
Finnerup, Nanna Brix [1 ]
Baastrup, Cathrine [1 ]
机构
[1] Aarhus Univ, Danish Pain Res Ctr, DK-8000 Aarhus C, Denmark
关键词
Spinal cord injury; Neuropathic pain; Musculoskeletal pain; Allodynia; Mechanisms; Treatment; CHRONIC NEUROPATHIC PAIN; MAGNETIC-RESONANCE-SPECTROSCOPY; DOUBLE-BLIND; PEOPLE; GABAPENTIN; HYPERSENSITIVITY; AMITRIPTYLINE; STIMULATION; PREVALENCE; ACTIVATION;
D O I
10.1007/s11916-012-0259-x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Patients with spinal cord injury (SCI) may experience several types of chronic pain, including peripheral and central neuropathic pain, pain secondary to overuse, painful muscle spasms, and visceral pain. An accurate classification of the patient's pain is important for choosing the optimal treatment strategy. In particular, neuropathic pain appears to be persistent despite various treatment attempts. In recent years, we have gained increasing knowledge of SCI pain mechanisms from experimental models and clinical studies. Nevertheless, treatment remains difficult and inadequate. In line with the recommendations for peripheral neuropathic pain, evidence from randomized controlled treatment trials suggests that tricyclic antidepressants and pregabalin are first-line treatments. This review highlights the diagnosis and classification of SCI pain and recent improvements in the understanding of underlying mechanisms, and provides an update on treatment of SCI pain.
引用
收藏
页码:207 / 216
页数:10
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