Enantioselective Diels-Alder Reactions with G-Quadruplex DNA-Based Catalysts

被引：126

作者：

Wang, Changhao ^{[1
]}

Jia, Guoqing ^{[1
]}

Zhou, Jun ^{[1
]}

Li, Yinghao ^{[1
]}

Liu, Yan ^{[1
]}

Lu, Shengmei ^{[1
]}

Li, Can ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 37期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; cycloaddition; Diels-Alder reaction; DNA; sequence-dependence; CARBON BOND FORMATION; ASYMMETRIC CATALYSIS; MACROPHOMATE SYNTHASE; DEFICIENT CONDITIONS; ORGANIC-SYNTHESIS; STRUCTURAL BASIS; RNA; WATER; CHEMISTRY; SEQUENCE;

D O I：

10.1002/anie.201204850

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA in command: An enantioselective Diels-Alder reaction can be achieved using human telomeric G-quadruplex DNA-based catalysts. The absolute configuration of the product can be reversed when the conformation of G-quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels-Alder reaction were found to be dependent on the DNA sequence. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9352 / 9355

页数：4

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