Autoimmunity and atopic dermatitis

被引:67
作者
Mittermann, Irene [1 ]
Aichberger, Karl J. [1 ,2 ]
Buender, Robert [3 ]
Mothes, Nadine [1 ]
Renz, Harald [3 ]
Valenta, Rudolf [1 ]
机构
[1] Med Univ Vienna, Vienna Gen Hosp, Div Immunopathol, Dept Pathophysiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Vienna Gen Hosp, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria
[3] Univ Marburg, Dept Clin Chem & Mol Diagnost, Marburg, Germany
基金
奥地利科学基金会;
关键词
atopic dermatitis; IgE autoreactivity; autoimmunity;
D O I
10.1097/00130832-200410000-00007
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of review It has been demonstrated that a considerable percentage of patients suffering from atopic dermatitis mount IgE autoantibodies against a broad variety of human proteins. This review summarizes evidence for autoimmune mechanisms in atopic dermatitis and suggests novel pathomechanisms that may be involved in this disease. Recent findings It has been shown that patients suffering from atopic dermatitis exhibit IgE autoreactivity to human proteins. These autoantigens are expressed in a variety of cell and tissue types. Complementary DNAs coding for IgE autoantigens have been identified, cloned and characterized at the molecular level. Using purified recombinant IgE autoantigens, it has been shown in paradigmatic models that IgE autoimmunity may be a pathogenetic mechanism in atopic dermatitis. Moreover, it has been shown that the levels of IgE autoantibodies are associated with severity of disease. Summary Patients suffering from severe manifestations of atopy mount IgE autoantibodies against a variety of human proteins. The levels of IgE autoantibodies correspond with disease severity. Several mechanisms of IgE autoimmunity may contribute to the pathogenesis of atopic dermatitis.
引用
收藏
页码:367 / 371
页数:5
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