How Salmonella became a pathogen

被引：239

作者：

Groisman, EA ^{[1
]}

Ochman, H ^{[1
]}

机构：

[1] UNIV ROCHESTER,DEPT BIOL,ROCHESTER,NY 14627

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 09期

关键词：

BACTERIAL VIRULENCE DETERMINANTS; TYPHIMURIUM INVASION GENES; EPITHELIAL-CELLS; YERSINIA-ENTEROCOLITICA; SHIGELLA-FLEXNERI; ESCHERICHIA-COLI; MOUSE-VIRULENCE; PEYERS-PATCHES; BALB/C MICE; HOST-CELLS;

D O I：

10.1016/S0966-842X(97)01099-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.

引用

页码：343 / 349

页数：7

共 74 条

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