Cardiac hypertrophy: sorting out the circuitry

被引:74
作者
McKinsey, TA [1 ]
Olson, EN [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Mol Biol & Oncol, Dallas, TX 75235 USA
关键词
D O I
10.1016/S0959-437X(99)80040-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cardiac hypertrophy is an adaptive response of the heart to a variety of intrinsic and extrinsic stimuli. The hypertrophic response, during which cardiomyocytes increase in size without undergoing cell division, initially serves to compensate for decreased cardiac output; however, prolonged hypertrophy can become detrimental, resulting in dilated cardiomyopathy and heart failure. Cardiac hypertrophy requires coupling of intracellular signal transduction systems with transcription factors that activate and maintain the hypertrophic program. Over the past year, signaling pathways involving G proteins, mitogen-activated protein kinases and calcium-responsive phosphatases have emerged as critical regulators of cardiac hypertrophy.
引用
收藏
页码:267 / 274
页数:8
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